PATCHing platelet data to improve transfusion
نویسندگان
چکیده
منابع مشابه
Redox Proteomics and Platelet Activation: Understanding the Redox Proteome to Improve Platelet Quality for Transfusion
Blood banks use pathogen inactivation (PI) technologies to increase the safety of platelet concentrates (PCs). The characteristics of PI-treated PCs slightly differ from those of untreated PCs, but the underlying reasons are not well understood. One possible cause is the generation of oxidative stress during the PI process. This is of great interest since reactive oxygen species (ROS) act as se...
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Today’s Web of Data is noisy. Linked Data often needs extensive preprocessing to enable efficient use of heterogeneous resources. While consistent and valid data provides the key to efficient data processing and aggregation we are facing two main challenges: (1st) Identification of erroneous facts and tracking their origins in dynamically connected datasets is a difficult task, and (2nd) effort...
متن کاملRefractory response to platelet transfusion therapy.
Platelet transfusions are commonly used for prophylaxis and treatment of bleeding. After a transfusion, an increment or "boost" is expected to occur. While a number of factors can contribute to a poor posttransfusion increment, refractoriness is typically defined as failure to achieve an appropriate increment after receiving 2 consecutive transfusions with fresh ABO-compatible platelets. The mo...
متن کاملThrombocytopenia and platelet transfusion
Thrombocytopenia is caused by disorders impairing platelet production, causing platelet destruction or leading to platelet sequestration. In addition, there are both congenital and acquired disorders of platelet function. These latter conditions may lead to the functional equivalent of thrombocytopenia, often despite the presence of a normal platelet count. Platelet transfusion represents an im...
متن کاملSingle donor platelet transfusion.
Cytopheresis equipment from a number of manufacturers now permits the rapid, safe, and efficient procurement of functionally normal platelets from single donors. There has been an extensive proliferation of these blood cell separators and virtually all large blood collection centers and most large hospitals have at least one blood cell separator in operation. Transfusions from single donors sel...
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ژورنال
عنوان ژورنال: Blood
سال: 2020
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.2020005384